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Year : 2018  |  Volume : 7  |  Issue : 12  |  Page : 69-74

Clinical pattern of human immunodeficiency virus-associated sensory neuropathy among adults in Kano, Northwestern Nigeria

1 Department of Medicine, Murtala Mohammed Specialist Hospital, Kano, Nigeria
2 Department of Medicine, Neurology Unit, Aminu Kano Teaching Hospital, Bayero University Kano, Kano, Nigeria
3 Department of Medicine, Infectious and Tropical Diseases Unit, College of Medical Sciences, Public Health and Diagnostic Institute, Yusuf Maitama Sule University Kano, Kano, Nigeria
4 Department of Medicine, Infectious and Tropical Diseases Unit, Aminu Kano Teaching Hospital, Bayero University Kano, Kano, Nigeria

Correspondence Address:
Aliyu Ibrahim
Department of Medicine, Neurology Unit, Aminu Kano Teaching Hospital, Bayero University Kano, No. 1 Zaria Road, PMB 3452, Kano
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/nnjcr.nnjcr_6_18

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Background: Peripheral neuropathy has implications for drug adherence and quality of life including the physical and emotional functioning in human immunodeficiency virus (HIV)-positive individuals. The debilitating impact on the ability to carry out their daily tasks is considerable and may sometimes become longstanding. The study assessed the frequency and determinants of HIV-associated sensory neuropathy (HIV-SN) in Kano, Northwestern Nigeria, with a view to provide optimal care. Methodology: A cross-sectional survey where the brief peripheral neuropathy screening (BPNS) benign familial neonatal seizures tool was administered to 380 HIV-positive clinic attendees using systematic random sampling was carried out. Potential risk variables were subjected to multivariate analysis modeling using logistic regression statistics to determine if they are independent predictors of the HIV-SN. Results: Of the 380 study participants, 263 (69.2%) were females, with a mean age of 37.4 ± 9.9 years. The mean CD4 count and duration of the diagnosis of HIV infection of the participants were 484.5 ± 254.9 cells/mm3 and 60.9 ± 43.5 months, respectively. Using the BPNS screening (BPNS) tool, 29.2% (111/380) of the participants had HIV-SN. Independent determinants of HIV-SN in our included age >40 years (odd ratio [OR] 5.86, 95% confidential interval [CI] = 2.48–13.88, P < 0.001) and type of highly active antiretroviral therapy combination used (OR 0.36, 95% CI = 0.17–0.73, P = 0.005). Conclusion: The frequency and determinants of HIV-SN prompt the need to strengthen early screening and treatment of HIV-infected patients by physicians managing them, to improve their overall quality of life.

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